Studies on Steroid Conjugates. VI. Synthesis of 17α-Estradiol 17-N-Acetylglucosaminide
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چکیده
منابع مشابه
Studies on P R O T E I N Synthesis I N Vitro Vi
The release of radioactive amino add from the particulate fractions separated from the prelabeUed livers of rats by centrifugation has been studied under various conditions. Although pure fractions may not have been obtained, great differences in behavior were observed. In the mitochondria and nuclei dinitrophenol (10 -4 ~) causes an inhibition of release, but in microsomes the opposite effect ...
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To characterize further the active site of human placental estradiol 17 beta-dehydrogenase (EC 1.1.1.62), we have synthesized 2-bromoacetamidoestrone methyl ether. The affinity-labeling steroid is a substrate for the homogeneous enzyme. It inactivates the enzyme in a time-dependent, irreversible manner which follows pseudo-first order kinetics. Further, inactivation conducted with varying stero...
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To further characterize the active site of human placental oestradiol17/3-dehydrogenase (EC 1.1.1.62), we have synthesized 4-bromoacetamidoestrone methyl ether. Starting with estrone, synthetic steps involved nitration, isolation of the I-nitro derivative with subsequent methylation, selective reduction of the nitro group, and coupling of the resulting 4-amino group with bromoacetic acid. The a...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1971
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.19.2183